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Patent cliffs & loss of exclusivity

1 upcoming patent cliff

DrugIngredientTypeCliff
  1. ANTIZOLFOMEPIZOLESmall mol.Jun 2027
  2. DOXYCYCLINE HYCLATEDOXYCYCLINE HYCLATESmall mol.—
  3. DOXYCYCLINE HYCLATEDOXYCYCLINE HYCLATESmall mol.—
  4. FENOPROFEN CALCIUMFENOPROFEN CALCIUMSmall mol.—
  5. FENOPROFEN CALCIUMFENOPROFEN CALCIUMSmall mol.—
  6. HYDROXYZINE PAMOATEHYDROXYZINE PAMOATESmall mol.—
  7. HYDROXYZINE PAMOATEHYDROXYZINE PAMOATESmall mol.—
  8. HYDROXYZINE PAMOATEHYDROXYZINE PAMOATESmall mol.—
  9. HYDROXYZINE PAMOATEHYDROXYZINE PAMOATESmall mol.—
  10. HYDROXYZINE PAMOATEHYDROXYZINE PAMOATESmall mol.—
  11. MECLOFENAMATE SODIUMMECLOFENAMATE SODIUMSmall mol.—
  12. MECLOFENAMATE SODIUMMECLOFENAMATE SODIUMSmall mol.—
  13. PROPOXYPHENE HYDROCHLORIDEPROPOXYPHENE HYDROCHLORIDESmall mol.—
  14. SULFINPYRAZONESULFINPYRAZONESmall mol.—
  15. VALPROIC ACIDVALPROIC ACIDSmall mol.—
  16. OXYMORPHONE HYDROCHLORIDEOXYMORPHONE HYDROCHLORIDESmall mol.—
  17. OXYMORPHONE HYDROCHLORIDEOXYMORPHONE HYDROCHLORIDESmall mol.—
  18. OXYMORPHONE HYDROCHLORIDEOXYMORPHONE HYDROCHLORIDESmall mol.—
  19. OXYMORPHONE HYDROCHLORIDEOXYMORPHONE HYDROCHLORIDESmall mol.—
  20. OXYMORPHONE HYDROCHLORIDEOXYMORPHONE HYDROCHLORIDESmall mol.—
  21. OXYMORPHONE HYDROCHLORIDEOXYMORPHONE HYDROCHLORIDESmall mol.—
  22. OXYMORPHONE HYDROCHLORIDEOXYMORPHONE HYDROCHLORIDESmall mol.—
  23. AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDESmall mol.—
  24. AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDESmall mol.—
  25. AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDESmall mol.—
  26. AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDESmall mol.—
  27. AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDESmall mol.—
  28. AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDESmall mol.—
  29. BROMPHENIRAMINE MALEATEBROMPHENIRAMINE MALEATESmall mol.—
  30. CHLORPROPAMIDECHLORPROPAMIDESmall mol.—
  31. CHLORPROPAMIDECHLORPROPAMIDESmall mol.—
  32. CLONIDINE HYDROCHLORIDECLONIDINE HYDROCHLORIDESmall mol.—
  33. CLONIDINE HYDROCHLORIDECLONIDINE HYDROCHLORIDESmall mol.—
  34. CLONIDINE HYDROCHLORIDECLONIDINE HYDROCHLORIDESmall mol.—
  35. CLONIDINE HYDROCHLORIDE AND CHLORTHALIDONECHLORTHALIDONE; CLONIDINE HYDROCHLORIDESmall mol.—
  36. CLONIDINE HYDROCHLORIDE AND CHLORTHALIDONECHLORTHALIDONE; CLONIDINE HYDROCHLORIDESmall mol.—
  37. CLONIDINE HYDROCHLORIDE AND CHLORTHALIDONECHLORTHALIDONE; CLONIDINE HYDROCHLORIDESmall mol.—
  38. CLOZAPINECLOZAPINESmall mol.—
  39. CLOZAPINECLOZAPINESmall mol.—
  40. DOXY-SLEEP-AIDDOXYLAMINE SUCCINATESmall mol.—
  41. HALOPERIDOLHALOPERIDOLSmall mol.—
  42. HYDRO-RIDEAMILORIDE HYDROCHLORIDE; HYDROCHLOROTHIAZIDESmall mol.—
  43. HYDROFLUMETHIAZIDEHYDROFLUMETHIAZIDESmall mol.—
  44. IBUPROFENIBUPROFENSmall mol.—
  45. IMIPRAMINE HYDROCHLORIDEIMIPRAMINE HYDROCHLORIDESmall mol.—
  46. IMIPRAMINE HYDROCHLORIDEIMIPRAMINE HYDROCHLORIDESmall mol.—
  47. LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMSmall mol.—
  48. LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMSmall mol.—
  49. LORAZEPAMLORAZEPAMSmall mol.—
  50. LORAZEPAMLORAZEPAMSmall mol.—
  51. LORAZEPAMLORAZEPAMSmall mol.—
  52. MEPROBAMATE AND ASPIRINASPIRIN; MEPROBAMATESmall mol.—
  53. METHOCARBAMOL AND ASPIRINASPIRIN; METHOCARBAMOLSmall mol.—
  54. METHYCLOTHIAZIDEMETHYCLOTHIAZIDESmall mol.—
  55. METHYCLOTHIAZIDEMETHYCLOTHIAZIDESmall mol.—
  56. METHYLDOPA AND CHLOROTHIAZIDECHLOROTHIAZIDE; METHYLDOPASmall mol.—
  57. METHYLDOPA AND CHLOROTHIAZIDECHLOROTHIAZIDE; METHYLDOPASmall mol.—
  58. METHYLPREDNISOLONEMETHYLPREDNISOLONESmall mol.—
  59. METHYLPREDNISOLONEMETHYLPREDNISOLONESmall mol.—
  60. METHYLPREDNISOLONEMETHYLPREDNISOLONESmall mol.—
  61. METOCLOPRAMIDE HYDROCHLORIDEMETOCLOPRAMIDE HYDROCHLORIDESmall mol.—
  62. OXANDROLONEOXANDROLONESmall mol.—
  63. OXANDROLONEOXANDROLONESmall mol.—
  64. PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE; PERPHENAZINESmall mol.—
  65. PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE; PERPHENAZINESmall mol.—
  66. PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE; PERPHENAZINESmall mol.—
  67. PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE; PERPHENAZINESmall mol.—
  68. PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE; PERPHENAZINESmall mol.—
  69. PROPANTHELINE BROMIDEPROPANTHELINE BROMIDESmall mol.—
  70. RESERPINE AND HYDROFLUMETHIAZIDEHYDROFLUMETHIAZIDE; RESERPINESmall mol.—
  71. SULFINPYRAZONESULFINPYRAZONESmall mol.—
  72. THIORIDAZINE HYDROCHLORIDETHIORIDAZINE HYDROCHLORIDESmall mol.—
  73. THIORIDAZINE HYDROCHLORIDETHIORIDAZINE HYDROCHLORIDESmall mol.—
  74. THIORIDAZINE HYDROCHLORIDETHIORIDAZINE HYDROCHLORIDESmall mol.—
  75. THIORIDAZINE HYDROCHLORIDETHIORIDAZINE HYDROCHLORIDESmall mol.—
  76. THIORIDAZINE HYDROCHLORIDETHIORIDAZINE HYDROCHLORIDESmall mol.—
  77. THIORIDAZINE HYDROCHLORIDETHIORIDAZINE HYDROCHLORIDESmall mol.—
  78. THIORIDAZINE HYDROCHLORIDETHIORIDAZINE HYDROCHLORIDESmall mol.—
  79. TOLAZAMIDETOLAZAMIDESmall mol.—
  80. TOLAZAMIDETOLAZAMIDESmall mol.—
  81. TOLAZAMIDETOLAZAMIDESmall mol.—
  82. TRICHLORMETHIAZIDETRICHLORMETHIAZIDESmall mol.—
  83. TRICHLORMETHIAZIDETRICHLORMETHIAZIDESmall mol.—
  84. FENTANYL CITRATEFENTANYL CITRATESmall mol.—
  85. FENTANYL CITRATEFENTANYL CITRATESmall mol.—
  86. FENTANYL CITRATEFENTANYL CITRATESmall mol.—
  87. FENTANYL CITRATEFENTANYL CITRATESmall mol.—
  88. FENTANYL CITRATEFENTANYL CITRATESmall mol.—
  89. FENTANYL CITRATEFENTANYL CITRATESmall mol.—

Loss-of-exclusivity dates are derived from the FDA Orange & Purple Books; company detail is from the CliffBio graph. Estimates are projections, not legal advice.

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