← Patent-cliff monitor small molecule ZORYVE ROFLUMILAST
Loss of exclusivity August 2037 latest FDA-listed patent expiry
Drug detail Brand name ZORYVE Active ingredient ROFLUMILAST Strength 0.05% Dosage form CREAM Route TOPICAL Modality Small molecule FDA approval October 2025 Marketing status RX
Listed patents Patent Expires Type 11129818 August 2037 use U-4301 11992480 June 2037 use U-4301 11819496 June 2037 use U-4301 12005051 June 2037 use U-4301 9907788 June 2037 use U-4301 12257242 June 2037 product 12011437 June 2037 product 12005052 June 2037 product 12042487 June 2037 product 9884050 June 2037 product 10940142 June 2037 product 12220409 June 2037 product 11793796 June 2037 product 12336983 June 2037 product 12310956 June 2037 use U-4301 12016848 June 2037 product
Regulatory exclusivity Code Expires NS October 2028
Source: FDA Orange Book, layered on the CliffBio company graph. Cliff dates are the latest FDA-listed patent expiry; estimates are projections, not legal advice.