small molecule

ORKAMBI

IVACAFTOR; LUMACAFTOR

Loss of exclusivityJune 2031latest FDA-listed patent expiry
CompanyVERTEX PHARMACEUTICALS INC

Drug detail

Brand nameORKAMBI
Active ingredientIVACAFTOR; LUMACAFTOR
Strength125MG;100MG
Dosage formTABLET
RouteORAL
ModalitySmall molecule
FDA approvalSeptember 2016
Marketing statusRX

Listed patents

PatentExpiresType
8993600*PEDJune 2031
8507534*PEDMarch 2031
8716338*PEDMarch 2031
8993600December 2030product
8716338September 2030product
8507534September 2030substance, product
9192606*PEDMarch 2030
12458635*PEDFebruary 2030
11564916*PEDFebruary 2030
10646481*PEDFebruary 2030
8846718*PEDJanuary 2030
9192606September 2029product
12458635August 2029product
10646481August 2029product
11564916August 2029use U-3529
8846718July 2029use U-1908
12065432*PEDJune 2029
10597384*PEDJune 2029
8653103*PEDJune 2029
11052075*PEDJune 2029
9150552*PEDJune 2029
10597384December 2028substance, product
11052075December 2028product
12065432December 2028use U-3984
8653103December 2028product
9150552December 2028use U-1908
8324242*PEDFebruary 2028
7495103*PEDNovember 2027
8324242August 2027use U-1911
9670163*PEDJune 2027
8754224*PEDJune 2027
8410274*PEDJune 2027
9931334*PEDJune 2027
7495103May 2027substance, product
7973038*PEDMay 2027
9216969*PEDMay 2027
8741933*PEDMay 2027
8410274December 2026product
8754224December 2026substance, product
9670163December 2026product
9931334December 2026product
7973038November 2026use U-1973
9216969November 2026product
8741933November 2026use U-1909

Source: FDA Orange Book, layered on the CliffBio company graph. Cliff dates are the latest FDA-listed patent expiry; estimates are projections, not legal advice.

ORKAMBI patent cliff — loss of exclusivity June 2031 | CliffBio