← Patent-cliff monitor Loss of exclusivity July 2038 latest FDA-listed patent expiry
Company VERTEX PHARMACEUTICALS INC
Drug detail Brand name TRIKAFTA (COPACKAGED) Active ingredient ELEXACAFTOR, IVACAFTOR, TEZACAFTOR; IVACAFTOR Strength 100MG, 75MG, 50MG;75MG Dosage form GRANULE Route ORAL Modality Small molecule FDA approval April 2023 Marketing status RX
Listed patents Patent Expires Type 12350262 July 2038 use U-4476 11179367 December 2037 product 10793547 December 2037 substance, product 11453655 December 2037 substance, product 11517564 December 2037 product 11426407 October 2035 substance, product 10758534 October 2035 substance, product 10272046 February 2033 product 11752106 February 2033 product 8883206 February 2033 product 12214083 February 2033 product 11147770 February 2033 product RE50453 July 2031 substance, product 10081621 March 2031 product 11578062 March 2031 product 10646481 August 2029 product 12458635 August 2029 product 11564916 August 2029 use U-4485 8415387 November 2027 use U-4476 8324242 August 2027 use U-4476 7776905 June 2027 substance, product 7495103 May 2027 substance, product 8623905 May 2027 substance, product 8598181 May 2027 use U-4476 7645789 May 2027 substance, product 9974781 April 2027 product 10239867 April 2027 substance, product 10022352 April 2027 product 11639347 April 2027 substance, product 9931334 December 2026 product 8410274 December 2026 product 9670163 December 2026 product 8754224 December 2026 substance, product 8354427 July 2026 use U-3593
Regulatory exclusivity Code Expires ODE-543 March 2033 ODE-512 December 2031 ODE-433 April 2030 NP April 2026
Source: FDA Orange Book, layered on the CliffBio company graph. Cliff dates are the latest FDA-listed patent expiry; estimates are projections, not legal advice.